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Thursday, August 6, 2020 | History

2 edition of Double minute chromosomes, P-glycoprotein expression, and multi-drug resistance. found in the catalog.

Double minute chromosomes, P-glycoprotein expression, and multi-drug resistance.

Scott McGregor Robertson

Double minute chromosomes, P-glycoprotein expression, and multi-drug resistance.

by Scott McGregor Robertson

  • 102 Want to read
  • 28 Currently reading

Published .
Written in English


The Physical Object
Pagination107 leaves
Number of Pages107
ID Numbers
Open LibraryOL14756958M

McGraw-Hill Ryerson Biology Authors Trent Carter-Edwards Upper Canada District School Board Susanne Gerards Ottawa Carleton District School Board Keith Gibbons London District Catholic School Board Susan McCallum York Region District School Board Robert Noble Toronto Catholic District School Board Jennifer Parrington Durham District School Board Clyde Ramlochan Toronto District School   Read the latest Research articles from Nature. Analysis of predicted loss-of-function variants from , human exomes whole genomes in

  Encyclopedia of Genetics, Genomics, Proteomics and Informatics--B_自然科学_专业资料 人阅读|34次下载 Encyclopedia of Genetics, Genomics, Proteomics and Informatics--B_自然科学_专业 The expression of the fetal acetylcholine receptor by RMS is an example of a specific opportunity to capitalize on the activated satellite cell phenotype and at the same time co-develop anti

The Bonferroni P values corrected for the total number of tested SNPs were (asymptotic P = *10−5) and (asymptotic P = *10−5), :// Camicia et al. Molecular Cancer Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Rosalba Camicia 0 Hans C. Winkler 0 Paul O. Hassa 0 0 Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse , Zurich, Switzerland Diffuse large B-cell lymphoma (DLBCL) is


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Double minute chromosomes, P-glycoprotein expression, and multi-drug resistance by Scott McGregor Robertson Download PDF EPUB FB2

Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.

P V Schoenlein, D W Shen, J T Barrett, I Pastan, and ; M M Gottesman Proc Natl Acad Sci USA –Baskin F, Rosenberg RN, Dev V: Correlation of double minute chromosomes with unstable multi-drug P-glycoprotein expression in uptake mutants of neuroblastoma cells.

Proc Natl Acad Sci USA –,   Stability and covalent modification of P-glycoprotein in multidrug-resistant KB Robertson SM, Ling V, and Stanners CP: Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.

Mole Cell Biol –, Google Scholar Chromosome Localization of P-Glycoprotein Genes in Drug-Sensitive and -Resistant Human Cells High level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes, Cancer J. R., and Ling, V., b, Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called Drug resistance is a fundamental problem in the treatment of cancer since cancer that becomes resistant to the available drugs may leave the patient with no therapeutic ://   P-gp.

Permeability glycoprotein (P-gp), also known as multidrug drug resistance protein (MDR) is found along the gastrointestinal tract (GIT) [], including the small intestine as primary site for the epithelial absorption of many orally administered drugs [].It has been shown that P-gp reduces the oral bioavailability of some anticancer drugs [].

1. Introduction. Multiple myeloma (MM) is a rare blood disease, representing 1% of cancers and 10% of all hematological malignancies, being the second most common blood cancer [1,2].MM is frequently associated with the elderly, as the majority of the patients are diagnosed between the age of 60 and 70; however, in recent years younger patients have been also diagnosed [3,4].

HAMADA, I-I. AND TSURUO, T. Characterisation of the ATPase actiitv of the Mr 1 70 to membrane gly coprotein (P-Glycoprotein) associated with Multi drug resistance in K ADM cells, cancer Research HANAHAN, D. Chapter 23 Cancer_自然科学_专业资料 人阅读|70次下载 Chapter 23 Cancer_自然科学_专业资料。第五版 分子细胞生物学 LODISH, et al., MOLECULAR CELL BIOLOGY, Fifth Edition Small cell lung cancer: Etiology, biology, clinical features, staging, and treatment the recently described overexpression of multi-drug resistance-related protein (MRP), and the expression of P-glycoprotein.

In mammals, gene amplifica- tion is frequently heralded by two karyotypic abnormalities, double minute chromosomes (DMC) and Multidrug resistance (MDR) is responsible for over 90% of deaths in cancer patients receiving traditional chemotherapeutics or novel targeted drugs.

The mechanisms of MDR include elevated metabolism of xenobiotics, enhanced efflux of drugs, growth factors, increased DNA repair capacity, and genetic factors (gene mutations, amplifications, and Multi-drug resistance (MDR) profile of GIST T-1R cells. (A) Expression of multi-drug resistance (MDR) proteins in GIST T-1 vs.

GIST T-1R cells. Expression of P-glycoprotein (MDR-1) remained unchanged, whereas expression of ABCG2 and MRP-1 slightly increased in GIST T-1R cells when compared to parental GIST T-1 :// Adriamycin (Adr), the single most active agent used in the treatment of breast cancer, may become ineffective as treatment progresses due to the development of multidrug resistant (MDR) tumors.

A major mechanism associated with MDR is increased P-glycoprotein (Pgp) expression. This thesis examined the abilities of the antiestrogen tamoxifen (TAM) and the progestin medroxyprogesterone acetate Resistance in the highly DDT-resistant R strain of Drosophila melanogaster involves decreased penetration, ABCB-type transporters expressed by multiple drug resistance (MDR) genes, such as p A.J.

CaplanDifferential effects of the organochlorine pesticide DDT and its metabolite p,p′-DDE on p-glycoprotein activity and :// Featured Articles. Featured articles by DR Lowy, the acting director of the NCI (), and A. Levine: DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.

Wang D, Qian X, Rajaram M, Durkin ME, Lowy :// Branimir I. Sikic, M. is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more).

The site facilitates research and collaboration in academic :// Patients with a high SNP score had poor EFS (HR =P = ), poor OS (HR =P = ) and greater proportion of MRD1 positive patients (P = ). Results were validated in patients enrolled in the children’s oncology group AAML standard arm, where high SNP score was associated with poor EFS (HR =P = ) and   年第一期医学总表 Hardcover USD; An Introduction to Scientific and Investigative Techniques 法医学:科学与调查技术导   Web view.

This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this   Web view.

Renal cell chemoresistance is a common occurrence; these lines often have a high abundance of multi-drug resistant (MDR1) protein expression, related to the levels of P-glycoprotein (Pgp). (30, 31) This increased expression means that drug efflux is This banner text can have markup.

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